A pattern was first utilized to the nanoACQUITY UPLC Trapping Column (Waters) utilizing water containing 0.1% formic acid as the cell part.

The exception to the rule is the DOT1 family, members of which methylate K79 in the globular region of histone H3 and which are structurally not associated to SET-domain proteins four - 6 Recent work means that SET-domain-containing proteins methylate a couple of proteins along with histones (see later)