PR-Set7-mediated monomethylation of histone H4 lysine 20 at particular genomic areas induces transcriptional repression. EZH1 mediates methylation on histone H3 lysine 27 and enhances EZH2 in maintaining stem cell identity and executing pluripotency. There are a variety of different methods to administer the Lysine. PR-Set7 is a nucleosome-particular methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin.

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